It is possible to restrict any affiliate's traffic to all of an advertiser's offers.
To do this, go to the advertiser, and once there, click on the AFFILIATE tab.
Once there, select the Affiliate or Affiliates that you do not want to be able to send traffic to the Advertiser and click on the Edit button.
Change the access to "Disabled" and click on the "Save" button.
From that moment on, if the affiliate sends traffic to any Advertiser offer, they will be considered to have no access. The fallback policy defined for the affiliate will be applied.
Note 1: This restriction applies to traffic, not the offer's visibility in the Marketplace. The Affiliate will continue to see the offer in the Marketplace.
Note 2: This restriction can be reversed by simply editing the Affiliate again, changing the access to Enabled and clicking on the "Save" button